No matter if it is moles, lumps, or skin discoloration, make sure you consult with your doctor.
Potential skin changes to keep an eye on are: moles with uneven borders, or change in color and size (probable signs of melanoma), constant sores that do not heal (may imply skin cancer), yellowing of the skin and eyes (jaundice) (related to liver or pancreatic cancer), dark spots or excessive itching (may indicate cancer of internal organs)
Persistent pain

Chronic pain that won’t go away even after you take medications and the amount of rest needed.
If the pain worsens over time, consult a doctor because it may be a sign of a more serious condition such as bone cancer (pain in the bones or fractures), brain tumors (causing persistent headaches, nausea, and vision problems), ovarian or colorectal cancer (causing pelvic or abdominal pain), or lung cancer (chest pain).
Unusual lumps or swelling
